Given these differences in the optimal diet for longevity extension and the intersection of their longevity functions in the range of more dilute diets, IIS and DR were argued to 'act through overlapping mechanisms' (Clancy et al., 2002).
It is possible that a reduction in bulk translation rates extends lifespan or that there is an increase in the translation of a subset of mRNAs encoding longevity functions (Zid et al., 2009).
Reduced IGF signaling was recently shown to be linked to the regulation of human lifespan (Suh et al., 2008; Willcox et al., 2008; Flachsbart et al., 2009), suggesting that the longevity functions of this pathway are conserved from worms to humans.
Another novel finding in this report is the discovery that TMEM135's pro-longevity function seems linked to DAF-16 modulation, since we were able to show that TMEM135 deletion or TMEM135 overexpression in vivo correlates with changes in DAF-16 levels.
Recent experiments in mice indicate that this pro-longevity function of Ras inhibition may be conserved.
As these results implicate WWP-1 as having both a stress resistance and pro-longevity function the authors next test whether the gene contributes to other known longevity pathways.
In this issue of Aging, workby Chua, McCord et al. suggests that SIRT6, a member of a protein family previously implicated in promoting longevity, may function at least in part via increasing efficacy of DNA repair.
Improvement of positioning and alignment by the use of computer-assisted surgery (CAS) might improve longevity and function in total knee replacements, but there is little evidence.
Improvement of positioning and alignment by using computer navigation might also improve longevity and function, but there is little evidence.
These results do not necessarily imply that mosquito miR-14 is important to longevity, a function of miR-14 demonstrated in D. melanogaster.
The longevity-modulating function of IGF-I in C. elegans displays a signal bifurcation involving the Ras ortholog Let-60, consistent with a role for RAS signaling downstream of IGF-IR.
