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In this qualitative review, we summarize recent findings on genetic factors linked to longevity across different populations and study designs.
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As discussed elsewhere (Harper et al., 2006), it may be that the precise cell type demonstrating cellular stress resistance, and hence critical to longevity, may vary across different long-lived mouse models.
We could indeed demonstrate large genetic differences across different lines exist, which set the basis for a QTL analysis of longevity in this species (see below).
Furthermore, the mitochondrial changes and longevity effects induced by CA are conserved across different species.
We suggest that it will be highly informative for future studies to examine longevity in mice, such as Irs1 nulls, across different genetic backgrounds.
Significant differences were found for longevity at different temperatures within the same clade (Table 2).
There remain unanswered questions around the effectiveness of brief alcohol intervention across different settings, different population groups, about the optimum intervention content, and the longevity of intervention effects.
Does this attitude cut across different cultures?
What trends exist across different groups?
"Alliances across different countries take different forms".
"You're going to come across different obstacles.
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