As shown by Deglau et al. researchers can think beyond delivery of therapeutics at the time of PCI, but can also engineer particle capture systems into the paving material to recharge the therapeutic for longer-term delivery.
As infant follow-up stopped at 2 years, we were not able to explore longer term implications of preterm delivery, such as developmental disabilities and cerebral palsy.
The funding available for this study only covered the six months of intervention delivery, and therefore longer term outcomes are not known.
It may take years before a new pay system delivers on some of its stated objectives; and if there is inadequate evaluation, this can hinder assessment of progress made in delivery of these longer term objectives.
The involvement and enhanced responsibility patients experience through this type of service delivery may have longer term gains for the patient's health, well-being and future healthcare usage; for example, reassurance to carers and relatives may impact on health and social care use over time.
The definitive trial would include longer follow-up to capture the longer term health and economic benefits of treatment delivery.
Higher mean levels of expression per cell obtained following DNA delivery and the longer duration of expression confirm a continuing role for DNA gene delivery in clinical applications that require longer term transient gene expression.
They provide potential advantages in oral delivery, patient tolerance and cost in the longer term.
Over the longer term, the platform hopes to be able to integrate with insulin delivery and other diabetes devices.
However, longer term, rigorous evaluations of the involvement of exercise physiologists, dietitians and GPs in delivery of weight loss interventions is needed to confirm this.
Economic modelling of the different delivery systems to evaluate their cost-effectiveness in both short-term and longer term infection patient groups.
