When telomeres get too short, a cell can no longer replicate, and ultimately dies.
It could be useful for cells that no longer replicate, like those in the brain.
After multiple replication cycles, the accumulation of mutations surpasses a crucial threshold beyond which the virus can no longer replicate.
These cell lines were derived from patients as far back as the '50s and maintained in the lab, but because of their age they no longer replicate in the same way that lymphoma grows in people.
No matter what Starbuck's flavor I tried, from Colombian to Christmas Blend, I fretted that I could no longer replicate the excitement of that first sip of smooth, rich flavor.
Highly mutated viruses can no longer replicate, and thus technology for producing viral vectors by the complementation of defective genes using complementing cells or packaging systems is impeded by low vector yields and contamination with wild-type virus rescuants.
Lately, I note, most of the essays and stories I write tend to be broken up into very short, numbered sections, because I can no longer replicate on the page the impression or sensation of consecutive, concentrated thought, because I don't really do that anymore.
When the caps are gone, the cell can no longer replicate.
As these chromosomes die, and cells can no longer replicate, old or damaged cells cannot be replaced.
However, there is a limit to how many mutations can be tolerated in the viral genome before it can no longer replicate.
