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The formulations can then be manufactured as aerosols, suppositories or patches which give the inhibitors a longer half-life and subsequently longer clearance [4, 65].
Propofol was switched to midazolam which, has a longer clearance time especially in the setting of liver or renal failure and increase duration of mechanical ventilation [ 7].
Other observations have revealed a longer clearance time on upper incisors for patients with active erosions and normal saliva values compared to patients with no erosion (Lussi, unpublished data).
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The suffering has been especially severe among black and Hispanic workers, who have had to wait longer for clearance than white workers.
The latter phenomenon has been mainly defined as an in vivo significant decrease in parasite reduction rate, manifested clinically by markedly longer parasite clearance times [5].
Within the group of non-ACT treated individuals, AUC was positively associated with the presence of asexual parasites on day three after treatment (i.e. a longer parasite clearance time), p = 0.046.
Both groups were prescribed the same antibiotics, and the longer fever clearance time in culture-positive patients may have been caused by higher bacterial loads.
Treatment failure was associated with increased pfmdr1 copy number, higher initial parasitemia, higher mefloquine IC50 and longer parasite clearance times [ 9].
Intermediate susceptibility to ciprofloxacin has been associated with longer fever clearance time and treatment failures when either ciprofloxacin or ofloxacin are used for treatment [ 10, 11].
AM treatment seemed to show longer parasite clearance time (percent of parasitemia patients on day 3): with 19% in Tak, 8% in Kanchanaburi, and 6% in Mae Hong Son; except 42% parasitemia on day 2 was observed in Ranong.
Pharmacokinetic analysis after intravenous administration of TW01003 indicated that TW01003 sulfate had a systemic bioavailability 2.5 times higher, volume of distribution three times higher, residence time seven times longer, and clearance rate 2.3 times lower compared to TW01003.
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