Sentence examples for long-term tolerance from inspiring English sources
The key issue that must be tackled is achieving a tolerable balance between immunosuppression and the associated side-effects and long-term tolerance.
In contrast, treatment with a CD4-specific mAb alone fails to induce long-term tolerance.
Once hyperacute rejection is circumvented, long-term tolerance of xenografted organs should be possible through a combination of transgenic immunomodulating molecule, bone marrow chimerism and short to intermediate term use of immunosuppressive drugs.
Ag-SP infusion also induces T regulatory cells that are dispensable for tolerance induction but required for long-term tolerance maintenance.
Lonicera pampaninii showed a poor adaptability to short-term P deficiency, but exhibited long-term tolerance under 0.125 mM P concentration.
In human patients that would confer an increased risk of infection, says Sachs, whose own lab is working on ways to induce long-term tolerance after organ transplants.
Second, drinking coffee while cortisol is high leads us to develop long-term tolerances for caffeine, which is why so many habitual coffee drinkers say it has less of an effect on them.
Although, the mechanisms by which continuous alloantigen exposure is required for DST-induced, long term tolerance have not been delineated, they may be related to the strength of proliferative response of CD4+ T-cells to donor antigen (Fig. 2B).
Indeed, adoptive transfer of CD4+CD45RC− T-cells obtained from rats that received DST and heart allograft into naïve recipients induced long term tolerance to heart allografts suggesting the presence of Tregs within this lymphocyte population[16].
Finally, we present the novel observation that virtually all of the Foxp3-expressing Tregs generated by DSTx4+LTx reside within the CD4+CD45RC− population and that these Tregs suppress alloantigen-induced activation in vitro as well as induce long term tolerance to liver allografts in vivo (Fig. 4A and 6C).
Treatment with a cocktail of CD4 and CD8-specific monoclonal antibodies (mAb) induces long-term transplantation tolerance and regulatory CD4+ T cells that induce tolerance in non-tolerant T cells.
