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Long-term specificity is for "the period thereafter (where the curve is flat)".
A window period is estimated, and then estimates of the sensitivity, short-term specificity and long-term specificity are determined with respect to the window period.
Our analysis shows that the McDougal estimator can be reduced to a formula that only requires calibration of a mean window period and a long-term specificity.
As we have shown, relaxing this assumption means that the long-term specificity becomes epidemic state dependent and hence is time dependent.
In order to calibrate the sensitivity, short-term specificity and long-term specificity, "a plot of the proportion of specimens positive in the assay versus time since seroconversion" is generated (also later referred to as "the curve").
Recently, we have also proposed a formally rigorous incidence paradigm [8], which accounts for assay non-progression using fewer assumptions than are made by McDougal et al. The parameters that emerge naturally in our estimator are a mean window period and a probability of not progressing on the assay (which can also be expressed as a long-term specificity).
Similar(42)
However, several challenges that significantly hinder the widespread utilization of microbial cell arrays remain, such as their limited viability and biological function after long-term storage, insufficient specificity, limited types of target analytes, and problems in genetic engineering of sensor strains (Table 2).
Besides, the designed immunosensor shows good reproducibility, long-term stability and high specificity.
The prepared ECL immunosensor exhibits high specificity, long-term stability and excellent reproducibility with a detection limit of 0.17 pg mL−1.
Besides, FeTSPc/SWCNTs displayed an even better specificity, long-term stability, tolerance to methanol crossover effect and resistance toward CO poisoning effect than the commercial Pt/C catalyst (40%).
Sensitivities of pCR and MNC to detect long-term survivors were 38%and61%1%, specificities were 84%and52%2%, respectively.
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