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Long-term sensitization to the excitatory effects of morphine.
Microarray analysis from 8 biological replicates suggests that long-term sensitization training rapidly regulates at least 81 transcripts.
Once optokindled, mice retained an elevated seizure susceptibility for several weeks in the absence of additional stimulation, indicating a form of long-term sensitization.
Morphine-induced long-term sensitization to the locomotor effects of morphine and amphetamine depends on the temporal pattern of the pretreatment regimen.
We used a custom-designed microarray and quantitative PCR to characterize the rapid transcriptional response to long-term sensitization training in the marine mollusk Aplysia californica.
One hour after training, pleural ganglia from the trained and untrained sides of the body were harvested; these ganglia contain the sensory nociceptors which help mediate the expression of long-term sensitization memory.
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Thus, both the structural changes and the synaptic facilitation of Aplysia sensorimotor synapses accompanying long-term behavioral sensitization can be produced in vitro by applying a single facilitating transmitter repeatedly.
We studied if maternal preeclampsia is associated with long-term allergic sensitization, allergic rhinoconjunctivitis, atopic dermatitis, asthma and with altered lung function in late childhood.
We recently reported that long-term insulin sensitization therapy with metformin during puberty in girls has cumulative auxological, body composition and endocrine-metabolic benefits.
In addition, Schmidt et al. recently showed that such a single administration of IL-1β to adult rats increases CRF and the CRF1 receptor mRNA expression in the PVN with a delay of one week after treatment which potentiates the secretion of ACTH and causes a long-term HPA sensitization [ 51].
Both long-term and short-term sensitization of the gill and siphon withdrawal reflex in Aplysia involve facilitation of the monosynaptic connections between the sensory and motor neurons.
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