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Our long-term hypothesis is that anatomically shaped tissue constructs of entire articular layers can be engineered in vitro on a bony substrate, for subsequent implantation.
Our long-term hypothesis is that volumetric and area-based density measures, when considered jointly with standard risk factors and BMI, can independently contribute to and improve breast cancer risk assessment, compared with percent density measures or standard risk factors alone.
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A very general problem (which we noted for instance in the context of cell migration) is the insufficient distinction between long-term hypotheses and well-founded theoretical models.
More long term hypotheses could include whether advice on ergonomically sound set-up promotes safe use and mitigates reversion to sitting because of injury and how standing and transition frequency change over the longer (than three months) term.
Given that delirium is a syndrome of acute brain dysfunction associated with long-term cognitive impairment, one hypothesis is that a similar persistent brain dysfunction increases sleep disruption in critical illness survivors [9, 37].
According to the scattered attention hypothesis, long-term media multitasking may lead to disrupted cognitive control in which the individual gravitates towards the preferred task rather than maintaining focus despite attentional distractions (van dur Schuur et al., 2015).
As a proof of concept, this prospective, randomized, open, long-term study tested the hypothesis that MDI with AI improves postprandial glucose better than human insulin (HI).
This suggests that even in the absence of a medical diagnosis based on organic pathology, time spent sharing medical and lay explanations and the relative safety of possible self-care strategies may reap long-term rewards - a hypothesis that is supported by evidence about the importance of explanations in medically unexplained symptoms [ 37].
Here, we tested in patients with primary breast cancer and long-term follow-up the hypothesis that monitoring of tumor-specific chromosomal rearrangements in cell-free circulating DNA can detect occult metastatic disease following primary surgery and serve as a sensitive, specific, and thus potentially clinically useful noninvasive biomarker in the adjuvant setting (Fig 1).
The second objective is to estimate CO2 flux from the Everglades Protection Area (EPA) marsh to the atmosphere and investigate long-term trends, with the hypotheses that aquatic CO2 fluxes will also decline concurrently with the decline in other C pools as a response to restoration.
The qualitative analysis provided a coherent framework for understanding long-term remission and generated hypotheses that can be tested in future studies.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com