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A very general problem (which we noted for instance in the context of cell migration) is the insufficient distinction between long-term hypotheses and well-founded theoretical models.
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Our long-term hypothesis is that anatomically shaped tissue constructs of entire articular layers can be engineered in vitro on a bony substrate, for subsequent implantation.
Our long-term hypothesis is that volumetric and area-based density measures, when considered jointly with standard risk factors and BMI, can independently contribute to and improve breast cancer risk assessment, compared with percent density measures or standard risk factors alone.
More long term hypotheses could include whether advice on ergonomically sound set-up promotes safe use and mitigates reversion to sitting because of injury and how standing and transition frequency change over the longer (than three months) term.
The second objective is to estimate CO2 flux from the Everglades Protection Area (EPA) marsh to the atmosphere and investigate long-term trends, with the hypotheses that aquatic CO2 fluxes will also decline concurrently with the decline in other C pools as a response to restoration.
The qualitative analysis provided a coherent framework for understanding long-term remission and generated hypotheses that can be tested in future studies.
This finding equally supports two hypotheses: long-term selection against insertion near genes versus the preferential insertion of new copies near genes pushing away old insertions.
Although this pharmacovigilance study has insufficient statistical power to draw conclusions and is limited by the lack of data on smoking history and other cardiovascular risk factors, these unique long-term outcome data generate hypotheses that warrant further investigation.
Given that delirium is a syndrome of acute brain dysfunction associated with long-term cognitive impairment, one hypothesis is that a similar persistent brain dysfunction increases sleep disruption in critical illness survivors [9, 37].
According to the scattered attention hypothesis, long-term media multitasking may lead to disrupted cognitive control in which the individual gravitates towards the preferred task rather than maintaining focus despite attentional distractions (van dur Schuur et al., 2015).
As a proof of concept, this prospective, randomized, open, long-term study tested the hypothesis that MDI with AI improves postprandial glucose better than human insulin (HI).
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