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Results show that moisture conditioning reduces the long-term healing rate by increasing the required activation energy for diffusion.
The long-term healing occurs only if there is a very long rest period and depends on the activation energy (or diffusion rate).
The anterior cruciate ligament (ACL) graft undergoes a long-term healing process known as "ligamentization" (Claes et al. 2011; Janssen & Scheffler 2014; Scheffler et al. 2008).
However, we aim to model much longer strengthening processes that correspond to the long-term healing process after the previous weakening process during a seismic cycle (e.g., Nakatani, 2001; Aochi and Matsu'ura 2002).
But, for chronic diabetic foot wounds that are not responding to months of appropriate therapy, the present study, together with most of those previously published, suggests that HBOT improves long-term healing.
Significant and complete healing of draining fistulas was observed in adalimumab-treated patients, and long-term healing of draining fistulas was maintained over 2 years from the baseline of the CHARM study.
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A healing model is developed to separate the total healing into instantaneous and long-term healings.
The scaffolds with high AC concentration (2.5 wt%) showed controlled drug release kinetics that are suitable for long term healing.
Elastic, stable intramedullary nailing for UBC demonstrated good to excellent results in almost all of the 47 UBCs, with long term healing within or during a 36-month period, and complications such as refracture and limb-length discrepancy [7].
It has been hypothesized that structural vascular support from a pediatric BAS for three to six months will be sufficient for long term healing [ 1, 9].
These data extend and define the beneficial effect of adalimumab on fistula healing in patients with CD and provide the first long-term fistula healing results with an anti-TNF therapy.
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