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(5) Long-term fed-batch simulation, where we verify model predictions against experimental data, and discuss population heterogeneity.
Long-term federal spending.
For all three genes, the expression was increased in the heart of long-term fat-fed versus chow-fed C57Bl/6 mice, but was less or unaffected in fat-fed versus chow-fed human apoB-transgenic mice (Fig. 4C).
Duration of breast-feeding was categorized into three groups: children who were never breast-fed, children who were breast-fed for a short time period (< 6 months), and long-term breast-fed children (≥ 6 months).
Overexpression of apoB attenuated triglyceride accumulation in the heart of long-term fat-fed obese mice.
These results suggest that increased lipoprotein formation in cardiac myocytes prevents triglyceride accumulation without affecting cholesterol or ceramide stores in hearts of long-term fat-fed obese mice.
These results suggest that increased lipoprotein formation attenuates changes in gene expression that increase uptake and metabolization of free fatty acids in the hearts of long-term fat-fed mice.
Studies have also been carried out on long-term galactose-fed dogs (Engerman and Kern, 1984).
Using quantitative RT PCR assays, we compare transcription of 28 key genes between short-term and long-term sugar-fed and starved females of the same age.
Second, we investigated transcriptional responses of 28 genes involved in lipid and sugar metabolism in short- and long-term sugar-fed females relative to starved females of N. vitripennis.
Similar to diabetic dogs, long-term galactose-fed galactosemic dogs have retinal lesions that resemble those seen in human DR (Takahashi et al., 1993; Kern and Engerman, 1996b; Kobayashi et al., 1998).
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