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Even if within-species HEG spread were possible for some reason, then escape from long-term degeneration would seem unlikely as one imagines horizontal transfer between metazoan germ-lines to be a prohibitively rare event.
One argument against tibiotalar arthrodesis is the frequently associated, long-term degeneration of the talonavicular joint, which can be attributed to changes in biomechanical stresses.
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High-dose ALN treatment was able to prevent early trabecular bone loss and cartilage degeneration following non-invasive knee injury, but was not able to mitigate long-term joint degeneration.
In his opening remarks, Smith, the director of the players' union, did not directly take issue with the N.F.L.'s approach, although in the statement he filed with the committee he assailed the N.F.L. for "denigrating, suppressing and ignoring" research that has linked football concussions to long-term cognitive degeneration.
Subchondral perfusion of osteochondral grafts has been shown to be important in preventing long-term cartilage degeneration.
Therefore, there is the need for alternative animal models for GSD-1a for studying both long-term liver degeneration and long-term effects of new therapeutic approaches.
Here, the reliably attainable lack of pain in the medium-term posed against the threat of long-term joint degeneration in the subtalar and transverse hindfoot joint ranks high on the list of current interests [ 2, 7, 8], and until now, there has been no clear evidence of either an alternative treatment or even a less drastic therapy regime.
That is our only hope for permanent, long-term deliverance from degeneration on this continent.
Proponents of TDR have hypothesized that by maintaining the mobility of the treated disc, long-term adjacent segment degeneration may be forestalled or possibly averted.
The observed long-term gliosis and degeneration warrant caution in the context of NSPC grafting for therapeutical purposes.
However, GA fixation of biological tissue is associated with long-term failure due to degeneration and calcification.
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