Long-term alterations in childhood growth and development are noted.
Such effects, when cumulative, found the bases for the long-term alterations observed.
To evaluate the long-term alterations of corneal nerves in patients with herpes simplex virus (HSV) keratitis using in vivo confocal microscopy (IVCM).
These results suggest that perinatal administration of PCP may produce long-term alterations in cognition that are revealed by pharmacological challenge and manipulation of task difficulty.
Our results suggest that direct and indirect human impact may produce long-term alterations to forest landscape patch structure that persist for decades to centuries.
Norepinephrine-dependent modulation of long-term alterations in synaptic strength, gene transcription and other processes suggest a potentially critical role of this neurotransmitter system in experience-dependent alterations in neural function and behavior.
The intoxicated animals showed a short-term normocitic anemia, but revealed long-term alterations in the motor activity in open-field, where they showed an increase in both ambulating and rearing.
There is some evidence that a traumatic life event can induce long-term alterations in corticotropin-releasing hormone (CRH) producing neurons in humans, which may play a role in the pathophysiology of anxiety disorders, including post-traumatic stress disorder (PTSD).
During the SIMBOX (Science in Microgravity Box) mission on Shenzhou-8, we investigated microgravity-associated long-term alterations in macrophageal cells, the most important effector cells of the immune system.
Recent studies have demonstrated an association between drug or beverage addiction of mothers with DNA methylation changes, a phenomenon that can mediate long-term alterations in gene expression (Kovatsi et al., 2011; Marjonen et al., 2015; Masemola et al., 2015; Philibert et al., 2012; Zhang et al., 2012).
We show that short-term exposure of cultures to ketamine at concentrations of ≥20 μg/ml leads to a significant cell loss of differentiated cells and that non-cell death-inducing concentrations of ketamine (10 μg/ml) can still initiate long-term alterations of dendritic arbor in differentiated neurons, including dendritic retraction and branching point elimination.
