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Its antidepressant action has been proposed to be linked to the potent and long-lasting suppression of REM sleep (Vogel et al. 1990).
Furthermore, we show that this PFC stimulation induces a long-lasting suppression of anxiety-like behavior (but not conditioned social avoidance) in socially stressed Thy1-Chr2 mice: an effect that is observed >10 d after the last stimulation.
Analysis of the recipients did not reveal a remarkable long-lasting suppression of systemic mBSA-specific immune reactions.
Despite their diversity, these receptors all couple to Gi/o-type G-proteins and produce long-lasting suppression of neurotransmitter release from the presynaptic cell.
A long-lasting suppression of thromboxane biosynthesis may be achieved by repeated low-dose administrations or by slow-release preparations of aspirin.
Moreover, while their actions in AS have yet to be fully elucidated, the long-lasting suppression of T-cell function apparent during treatment with Infliximab suggests that neutralisation of soluble TNF cannot be the only mechanism [ 29].
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This individualized approach facilitates not only the transfection of a wide variety of cell types, but results in profound and long-lasting gene suppression after siRNA transfection.
Since our technical solution allows profound and long-lasting gene suppression after transfection of specific siRNA, we anticipate its use for a broad spectrum of normally hard-to-transfect cell populations including primary cells, and for a variety of siRNA applications.
Because of differences in the time course of recovery between cortical and thalamic cells, however, it seems unlikely that inheritance of thalamic response properties fully accounts for long-lasting forward suppression (Wehr and Zador 2005).
We next tested whether pre-treatment of MM cells with the DNA demethylating agent 5-aza-cytidine (Aza, 500 nM) might render MM cells more permissive for inducing a more long-lasting growth suppression after Bz treatment.
Inhibition of viral replication with agents such as novel nucleotide analogues may enhance the likelihood that therapeutic stimulation of the antiviral T cell reaponses will induce long-lasting viral suppression and HBV antigen seroconversion, ultimately leading to recovery from disease.
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