Changes in the strength of synapses are thought to underlie learning and memory, and long-lasting changes in synaptic strength involve increases or decreases in the number and size of dendritic spines.
Current Research and Scholarly InterestsLong-lasting changes in synaptic strength are important for the modification of neural circuits by experience.
The opposite of LTP is long-term depression, which produces a long-lasting decrease in synaptic strength.
The basic concept of the Marr Albus theory is that the climbing fiber serves as a "teaching signal", which induces a long-lasting change in the strength of parallel fiber inputs.
We demonstrated that these receptors can induce a long-lasting enhancement in synaptic strength that is Ca2+ dependent, but surprisingly independent of CaMKII, a crucial regulator of NMDAR-dependent LTP.
Changes in the morphology of these structures are associated with long-lasting modulation of synaptic strength thought to underlie learning and memory, and can be abnormal in neuropsychiatric disease.
Repeated high-frequency electrical stimulation to other regions of the hippocampus typically causes a long-lasting boost in the strength of synapse; this is called long-term potentiation.
At the molecular level, experience-dependent synaptic plasticity triggers new gene and protein expression necessary for long-lasting changes in synaptic strength.
Such heterogeneity would be consistent with the idea that LTP is not a single phenomenon, but rather a collection of mechanisms that can produce a long-lasting increase in synaptic strength (Malenka and Bear, 2004).
We also examined the impact of TRPML1 loss on synaptic plasticity by analyzing long-term potentiation (LTP), a long-lasting enhancement of synaptic strength induced by patterned high-frequency stimulation, which is thought to model synaptic modifications underlying learning and memory.
And while cardio exercise is vital to long-lasting health, it's the strength-training that helps you maintain and regain strength and improve metabolism so that you burn calories for much longer after workouts.
