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Exact(28)
Taken together, that means that most of the subjects in the study, about 56 percent — a figure that includes those whose disease never remitted — had no long-lasting remission of diabetes after surgery.
The main advantage of biological method, which will rely on application of E. coli Nissle 1917 strain as a carrier for specific recombinant colicins against AIEC strains, could probably cause a long-lasting remission of inflammation in CD and UC patients.
Pamidronate was reported to induce rapid and long-lasting remission in most CNO patients [6, 8, 49 52].
There is general agreement that the causative agent should be identified at the onset and intensely treated in order to achieve long-lasting remission but prompt diagnosis and individuation of pathogens are still difficult.
The largest series to date comprises 19 severe dCCH patients [33]: after a mean follow-up of 8.7 years, long-lasting improvement was present in 71% (12/17) with 6 persistently almost pain free and another 6 no longer experiencing daily attacks but episodic attacks interspersed with long-lasting remission [33].
After a long-lasting remission period NSAID treatment was stopped.
Similar(32)
Among the biggest challenges are increasing the response rate among patients and turning initial responses into long-lasting remissions.
Researchers say the treatment may be more promising as part of a combination than when given alone because, although some patients in the small study have had long-lasting remissions, many others had relapses.
Similarly, adoptive transfer of ex vivo-expanded autologous tumor antigen-specific CTLs for cancer immunotherapy is restricted by the fact that expanded T cells display limited survival upon transfer to recipients and long-lasting remissions are observed only in a fraction of patients [1], [11].
Although the long-term follow-up shows long-lasting remissions, within longer follow-up the number of relapses increases.
Apart from remarkable exceptions (e.g. chronic myeloid leukemia), many targeted therapies fail to achieve long-lasting remissions and cancer cells become resistant to treatment over time.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com