cancer therapies usually require a long lasting concentration or expression in the target organ in order to have therapeutic effects.
The applications of this success would be in the following aspects: cancer therapies usually require a long lasting concentration or expression in the target organ in order to have therapeutic effects.
Under these conditions biomarkers that have short peak concentrations at defined disease states may have lower prognostic values compared with those with long-lasting elevated concentrations.
Moreover, because of short drug half-life, local drug injections always failed to maintain long-lasting high concentrations on scar; therefore, repeated injections are often needed [6].
Biodistribution studies carried out in B16F0 murine melanoma tumour-bearing mice highlighted that acridone 8f and acridine 9d, presented high, long-lasting tumour concentrations together with an in vivo kinetic profile favourable to application in targeted radionuclide therapy.
Thus, the patients showed long-lasting low CSF CRH concentrations, in spite of changed CSF somatostatin concentrations and clinical amelioration.
A sharp and long-lasting decline in TP concentration, affecting all flow levels, took place after a major flood in 2002.
It is consistent with the idea that effect of BDNF on gamma oscillations is indirect and may be mediated by molecules like 5-HT3 receptor, whose expression or activity are altered during long-lasting reduction in BDNF concentration in KO mice and cannot be reversed rapidly.
Severe thermal injury is accompanied by long-lasting elevated plasma catecholamine concentration.
Therefore, the long-lasting effects of low concentrations of chemicals on abnormal phenotypes might be attributable to epigenetic alterations; chemicals that disturb the epigenetic status are termed epimutagens.
Whereas supplementation of ubiquinone and vitamin E in low concentrations is rather harmless, high concentrations and long-lasting application have been shown to increase the risk of bleeding in patients due to their anticoagulant effects [136, 151].
