However, maintenance of signalling over long time leads to the activation of secondary and tertiary transcription factors.
In addition, the perceived dissimilarity between the worlds of science and business has for a long time led many researchers to hold a lingering skepticism of commerce.
These results suggested that hypoxia maintained over a long time led LLC cells to enhance TGF‐β‐mediated responses via Smad phosphorylation.
He was picked, many believe, because it was politically unfeasible for the board to name Temple Sloan, the long-time lead director, as chairman.
The implications are that top-tier studios Metro-Goldwyn-Mayer, long-time lead producer for the franchise, and Sony Pictures Entertainment, which is co-financing and handling the film's marketing and distribution, altered the production and script to please Mexican backers for millions in cash and savings in exchange for portraying the country positively.
The "important" finding raises concerns that "increases in mortality could, if sustained over a long time, [lead] to degradation of the forest" with fewer old-growth trees, says Steven Wofsy, a geochemist at Harvard University who did not participate in the research.
For a long time, the lead investigator in the disappearance of Karen Mitchell in Eureka was a detective named Dave Parris.
"Arsenic in groundwater has been a problem for a really long time," said lead author Ryan Smith, a doctoral candidate in geophysics at the School of Earth, Energy & Environmental Sciences Stanford Earthh).
"For these toddlers, laying in bed awake for such a long time can lead to the association of bed with arousal, not sleep," she said.
Accordingly we have formulated a hypothesis that persistent c-Neu kinase activation for long time periods lead to promotion of malignant phenotype of affected cells.
These 'remote' doses have relatively low weights but, if taken for a long time, can lead to an important cumulative effect.
