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Previous long term studies examining the mdx diaphragm in the context of reduced myostatin signaling have reported some histological benefit, but have not demonstrated functional improvement [7], [15].
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WYCAP is a long term study examining the natural history of respiratory symptoms in two general practice populations in a deprived area of Manchester [ 20].
Long-term studies examining vegetation changes from the period before agricultural industrialisation are however rare.
Long-term studies examining CRC rates in patients with previous colonoscopy are lacking.
However, long-term studies examining target-organ protection may more fully illustrate the BP-independent benefits of specific antihypertensive agents.
Long-term studies examining an expansion of health insurance in Massachusetts eight years ago found ER visits declined or were unchanged.
Although long-term studies examining glycemic durability with glinides (nateglinide, repaglinide) in T2DM are not available, nateglinide failed to prevent prediabetic (IGT) patients from progressing to T2DM (115).
In diabetic humans, pioglitazone (157) and rosiglitazone (158) reduce albuminuria, although long-term studies examining effect of thiazolidinediones on GFR have not been performed.
Long-term studies examining patient response to TAM and TAM-induced toxicities versus UGT1A4 genotypes will be necessary to more fully evaluate the role of UGT genotypes on TAM therapeutic efficacy.
Future long-term studies examining the efficacy of canagliflozin with other antihyperglycemic medications will be needed; however, the unique and distinct mechanism of glucose lowering with canagliflozin suggests that combination efficacy may be observed when this agent is added to other classes of agents.
The TAs that were used as a source of genomic DNA were originally collected as part of long term longitudinal studies examining cytokine concentrations and the development of CLD[ 22, 23].
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