In summary, the Mf data reflect the long-term sterilization of O. volvulus after treatment with doxycycline, whereas fertility of female worms was not reduced in placebo patients.
Clinical trials have shown that doxycycline treatment eliminates Wolbachia, causing long-term sterilization of adult female filariae and effecting potent macrofilaricidal activity.
In the search for an optimized formulation, the current investigation is the first study on long-term sterilization effects of intratesticular injection of CaCl2 in either lidocaine solution or alcohol in dogs.
DeStefano et al[ 13], in their long term follow up of sterilized women found an increased risk of menstrual abnormalities even after a long period of 49 to 87 months after sterilization.
The formulations were stable to sterilization by γ-irradiation and long term storage under freezing.
In our preliminary test, no substantial loss of organotins was observed on γ-ray irradiation, and thus irradiation-sterilization was performed for CRM7306-a to ensure long term stability.
6 The newly released long term follow-up of a phase III study observed no pregnancy following hysteroscopic sterilization.
"Think long term," he said.
