It is important to bear in mind, however, that metformin is associated with a higher rate of treatment failure and that its long term safety remains unknown.
Despite improved knowledge of prognostic factors and advances in treatments for ovarian cancer, the outcome in terms of long-term survival remains unknown.
But even as the long-term effect remains unknown, the short-term impact is clear: Individuals and small businesses are absorbing the bulk of these losses, as states, government agencies and insurance companies help foot nature's bill.
Whether this is associated with a long-term risk remains unknown.
Preterm nutritional guidelines are based on consensus expert opinion 1 2 rather than compelling evidence and the 'optimal' diet for long-term health remains unknown.
Its long-term clinical course remains unknown.
The impact of early intervention on long-term cost saving remains unknown.
While this pattern of findings supports a "more is better" approach, the optimal frequency and comprehensiveness of self-monitoring necessary to achieve long-term weight maintenance remains unknown.
Yet, the number of projects is still limited, and long-term effects and efficiency remains unknown.
Despite partial recovery of GFR, the long-term outcome of nephrotoxicity remains unknown and careful monitoring of chronic toxicity is necessary.
