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This may represent a type of long term regulation.
A muscle specific promoter driving rtTA expression was required to obtain long term regulation using an adenoviral vector [26].
This suggests that the observed suppression is sequence-specific and that long term regulation of endogenous gene expression can be achieved in mammalian cells using convergent transcription.
Nitric oxide (NO) has been shown to be of significance and relevance for short and long term regulation of myocardial function and gene expression.
Given findings that GLO1 mitigates aging-associated endothelial dysfunction, which causes CVD in the long term, regulation of glycative stress may represent a versatile target for the prevention of vascular aging and CVD.
Histone methylations are well suited for deciding on cell fate and long-term regulations, as they can favor transcription (H3K4me) or attenuate transcription (H3K27me), depending on the site of modification.
Ghrelin, known mainly as a short-time regulator, is also involved in a long-term regulation.
Long-term regulation processes appear to monitor fat levels and to initiate eating when fat stores fall below some optimal level.
A second mechanism, called long-term regulation, is directed toward storing away sufficient energy for possible later use should the short-term mechanism fail to adequately replenish energy expended.
Less is known about the long-term regulation of hunger motivation, but one suggestion has been that there exists in each individual a genetically programmed body-weight set point that determines how much energy is stored away as fat within the fat cells.
In contrast to common long-term regulation, the utility function here changes on a smaller time-scale.
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