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In the present study, we were interested whether surfactant-associated liposome formulations could be designed to retain their physicochemical properties under long-term refrigerated storage and following aerosol delivery using nebulizers.
Time for shipment and transfer to long-term refrigerated storage and mean kinetic temperature during the shipment phase was 8.6 days/10.3°C and 13.4 days/12.1°C, for the first and second simulation studies, respectively.
Because ciprofloxacin is poorly soluble at neutral pH, the external pH of the surfactant-liposome mixture was reduced to 5.2, 4.9, and 4.7 to improve the likelihood that the released ciprofloxacin would remain in solution during long-term refrigerated storage.
This study demonstrates that it may be possible to provide a range of release profiles by simple addition of surfactant to a liposomal formulation post manufacture, and that these formulations may retain their physicochemical properties after long-term refrigerated storage and following aerosolization by mesh nebulizer.
You may want other creature comforts such as long-term refrigerated food storage, a clothes washer and dryer etc.
"Think long term," he said.
I'm looking long term.
And in the long term?
Long term?
What about long term?
Long term, it.
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