Sentence examples for long term gene expression from inspiring English sources
The novel vector series termed pEPito was superior in expression strength both in vitro and in vivo and exhibited strongly improved establishment efficiency as a non-integrated episome leading to long term gene expression.
Gene transfer resulted in rapid uptake and long-term gene expression in mice, rats, and non-human primates.
These results demonstrate that lentiviral vectors expressing BMP-2 can induce long-term gene expression in vitro and new bone formation in vivo under the control of the RhMLV promoter.
Gene therapy has the potential to introduce neurotrophins into the cochlea with long-term gene expression arising from a single surgical intervention to the cochlea, potentially coinciding with cochlear implantation.
The success of gene therapy relies on the efficient delivery of the genetic material to target cells, achieving optimum long-term gene expression.
The Sleeping Beauty transposon system (SB) has been shown to mediate nonviral integration of expression constructs resulting in long-term gene expression in several mammalian targets.
Adeno-associated virus (AAV) vectors have gained a preeminent position in the field of gene delivery to the normal brain through their ability to achieve extensive transduction of neurons and to mediate long-term gene expression with no apparent toxicity.
Since LVs can transduce a wide array of cells, support long-term gene expression, and be modified to enhance cell targeting, LVs are a powerful modality to deliver life-long therapeutic proteins.
Phage ΦC31 integrase has emerged as a potent tool for achieving long-term gene expression in different tissues.
The circularization events are stimulated by the ITRs, and the created double-strand episomes are stable and capable of long-term gene expression.
Recent studies have demonstrated the successful use of ΦC31 integrase, which can catalyze the integration of plasmids into the mammalian genome at so-called "pseudo-attP" sites to achieve long-term gene expression [21] [24]if those plasmids contain the attB recognition sequence.
