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The 2nd generation (1980 2010) was dedicated to the development of zero-order release systems, self-regulated drug delivery systems, long-term depot formulations, and nanotechnology-based delivery systems.
Targeting high-density human foveal ganglion cells with chemical photoswitches may rapidly generate high resolution vision, and developing either photoswitches with longer physiological half-lives or delivery strategies providing long-term depots could make chemical photoswitches an option of choice.
The cortical bone of the tibia represents a long-term storage depot with an elimination half-life for lead in excess of a decade.
Note 9: Long Term Debt.
The railway had recently leased out the 350,000-square-foot depot long term to a public-private entity called Grandi Stazioni to develop and said its hands were tied.
A potent GnRH antagonist, orntide, that shares with other GnRH analogues the need for a loading dose, is being developed in depot formulations (microspheres) for long term administration (months-years) [ 12- 14].
Injectable depot medroxyprogesterone may cause amenorrhea and adversely affect BMD if used long term (>2 years) [104].
It's very long term.
"Think long term," he said.
Long term?
What about long term?
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