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Long term alterations in brain function have been reported which could be related to long lasting cognitive impairments associated with malnutrition [ 4].
Since the same enzymes regulate nuclear gene expression during long term alterations in the calcium signals, they thus regulate differentiation, growth, metabolic and functional specializations, and eventually shape the phenotype of the muscle cells during development and pathogenesis [ 3, 4].
Observations in other polyploid species, including cotton [ 32, 76], oilseed rape [ 73] and Spartina[ 80], suggest there are both immediate and long term alterations in homoeologous gene expression patterns after polyploidization.
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Long-term alterations in childhood growth and development are noted.
These results suggest that perinatal administration of PCP may produce long-term alterations in cognition that are revealed by pharmacological challenge and manipulation of task difficulty.
Norepinephrine-dependent modulation of long-term alterations in synaptic strength, gene transcription and other processes suggest a potentially critical role of this neurotransmitter system in experience-dependent alterations in neural function and behavior.
The intoxicated animals showed a short-term normocitic anemia, but revealed long-term alterations in the motor activity in open-field, where they showed an increase in both ambulating and rearing.
There is some evidence that a traumatic life event can induce long-term alterations in corticotropin-releasing hormone (CRH) producing neurons in humans, which may play a role in the pathophysiology of anxiety disorders, including post-traumatic stress disorder (PTSD).
During the SIMBOX (Science in Microgravity Box) mission on Shenzhou-8, we investigated microgravity-associated long-term alterations in macrophageal cells, the most important effector cells of the immune system.
Recent studies have demonstrated an association between drug or beverage addiction of mothers with DNA methylation changes, a phenomenon that can mediate long-term alterations in gene expression (Kovatsi et al., 2011; Marjonen et al., 2015; Masemola et al., 2015; Philibert et al., 2012; Zhang et al., 2012).
Our results demonstrate that synchronous network activity is sufficient to produce stable, long-term alterations in the strength of active afferent connections.
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