A long-standing paradigm in tissue engineering is to induce tissue repair by the transplantation of cells alone or cells combined with biomaterial scaffolds.
PHRs and PHAs invert the long-standing paradigm of health care institutions as the authoritative data-holders and data-processors in the system.
This perspective supports the emerging recognition that the long-standing paradigm of cancer origination from isolated genetic mutations must be supplanted by an enlarged one in which the concerted action of dysregulated oncoproteins overwhelm cellular defenses against cancer proliferation.
According to a long-standing paradigm, the mechanism underlying this phenomenon is the reduced HSC pool in aged individuals.
The navigational strategies of insect larvae represent a long-standing paradigm for studying the mechanisms of animal orientation (Loeb, 1918; Mast, 1938).
A long-standing paradigm in B cell immunology is that effective somatic hypermutation and affinity maturation require cycling between the dark zone and light zone of the germinal center.
The findings that CTCs are detected even in early-stage non-metastatic cancer patients indicate that tumor dissemination occurs in a much earlier time frame than previously thought, directly challenging the long-standing paradigm that metastatic initiation is a later event in tumorigenesis.
In fact, although Brachyury orthologs have not been found in plants, genes related to Brachyury have been identified recently in the fungus Spizellomyces punctatus and in the amoeba Capsaspora owczarzaki [ 91], shifting the long-standing paradigm that considered Brachyury and its related genes as metazoan-specific innovations.
In music, in movies and in publishing, Apple has upended long-standing paradigms and altered the media landscape.
But when you think of a country with the potential of Brazil, that since the start of this century has managed to break long-standing paradigms and create new ones—how can it be possible to keep doing that sort of politics?So the question is, how to move to a new political model?
Global health attempts to change well-established and long-standing paradigms of research and practice as well as established metrics of excellence.
