Thirty-seven teachers from six schools, including Soraya's, received nine days of training, followed by a three month-long sensitization programme during which they also trained 70 teenage students as peer educators.
Microarray analysis from 8 biological replicates suggests that long-term sensitization training rapidly regulates at least 81 transcripts.
We used a custom-designed microarray and quantitative PCR to characterize the rapid transcriptional response to long-term sensitization training in the marine mollusk Aplysia californica.
One hour after training, pleural ganglia from the trained and untrained sides of the body were harvested; these ganglia contain the sensory nociceptors which help mediate the expression of long-term sensitization memory.
Specifically, we show that long-term sensitization training rapidly up-regulates the expression of transcripts which may encode Aplysia homologs of a C/EBPγ transcription factor, a glycine transporter (GlyT2), and a vacuolar-protein-sorting-associated protein (VPS36).
A form of learning in the marine mollusk Aplysia, long-term sensitization of the gill- and siphon-withdrawal reflex, results in the formation of new synaptic connections between the presynaptic siphon sensory neurons and their target cells.
Furthermore, specific dural mast cell degranulation produces a long-lasting sensitization of trigeminal primary afferent neurons [88, 156], suggesting this neuro-inflammatory mechanism may be directly involved in mediating the underlying neurophysiological changes that results in primary headache, particularly in migraine.
In the naked mole-rat, at a high enough concentration, application of SP caused a large, immediate, and long-lasting sensitization of foot withdrawal latency that was transiently reversed by application of either antagonist.
Serotonin (5HT) triggered growth of new presynaptic varicosities, a synaptic mechanism of long-term sensitization.
