Short-term or long-term readouts like heartbeat, mechanical contraction, viability, hERG activity, or Ca2+ fluxes are easy and straightforward to measure, thereby offering a sensitive model to assess cardiac toxicity.
Clearly, we're going to need to see the long-form digital readout from the scale Dr. Ronny Jackson used #Girther https://t.co/fFAMopGxZ1.
PMM can, in principle, be applied to any kind of parallel RNAi screens almost independently of the underlying biology or field of application as long as the readouts of the screens are measured on the same scale.
The experimental requirements suggest 20 cm long ladders and a readout pitch of around 240 μm.
Besides high sensitivity, the Raman scatter possesses 10~100 times narrower bands than those of fluorescence and excellent anti-photobleaching properties, which avail to reduce undesirable spectral overlap and provide long and stable signal readout [9].
The situation can be compared to that in astronomy, in which the telescope mirrors, despite their increasing size, have not changed for a long time, but the readout elements, starting from simply looking through the telescope, via print film to highly sensitive charge-coupled devices and other sensors, have improved the instrument dramatically.
We reasoned that the readout of long-term, context-independent priors should not depend on specific patterns of population activity driven by higher-level inferences.
