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Pharmacokinetic (PK) parameters such as long lung retention, high lung deposition, high receptor binding, and high lipophilicity have been sought to improve or maintain the pulmonary-targeted efficacy [11].
Duleep Allirajah, head of policy at Macmillan Cancer Support, said: "For too long lung cancer has been one of the more overlooked cancers, despite being the UK's biggest cancer killer.
For too long, lung cancer has been singled out as the "smoker's disease" when, in fact, it is one of many smoker's diseases.
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Tag on to this the physical capacity necessary to cope with long, lung-bursting periods of ferocious running: stretches of rugby in which the ball is in play for three minutes or more.
Furthermore, it is the inhaled corticosteroid molecules with highest potency, longest lung retention, lowest oral bioavailability and highest systemic clearance (FF, MF, FP, CIC) that have the highest therapeutic index.
The exception to this is FF, which has the longest lung retention and highest potency, where administering the same total daily dose as either a once-daily or twice-daily regimen has equivalent efficacy [ 15].
The main consequence of this appears to be a longer duration of action rather than greater efficacy per se, with the corticosteroid with the longest lung retention time (FF) being suitable for once-daily dosing, and those with shorter lung retention times requiring twice- (FP), three- or four-times (TAA) daily dosing regimens [ 7].
For humans, no one denies the need for long-term studies; the rat 90-day trial could be compared with a tobacco smoking trial in human teenagers which is stopped in their 20s, long before lung cancer becomes apparent.
Asthma is a chronic (long-term) lung condition.
The Fault in Our Stars is about Hazel Grace Lancaster, a long-term lung cancer victim.
3. Impact of airway hypoxia, due to lack of bronchial circulation, on long-term lung transplant outcomes.
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com