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As well, these results corroborate data obtained in cats, showing a long lasting response synchronization [8] or receptive field plasticity [10] of cortical visual cells after co-application of cholinergic agonists and light stimuli.
The median time to PSA progression was 126 days, indicating that multiple therapy cycles may be necessary to obtain a long lasting response.
In order to elucidate how Rage receptor signaling converts a transient stimulus into a long lasting response, global gene expression kinetics were recorded with skin samples of wt and Rage -/- mice upon TPA stimulation.
Such a sustained and long lasting response may lead to different biological outcomes than the ones resulting from ERK-PP activity that decays to zero at steady-state [ 25].
Three patients displaying a long lasting response to SM treatment (Table 1, Pts #6a,8a,10a; SD or PR according RECIST evaluation after ⩾10 months) consistently showed a low level of mMDSCs, with values comparable to HDs and no evidence of CD3+ T-cell dysfunction in the peripheral blood could be detected in these SM-responsive patients.
The estimated median Disease Free Interval, in the eight treated patients, was 28 months (95% CI=(11, NA), range=(9 59)). Figure 2 is an example of long lasting response to adjuvant RIT in a patient who had surgery for glioblastoma, showing a good response to RIT.
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These data confirm high activity of MACOP-B in adult LCH, indicating that a substantial fraction of patients achieve long lasting responses and can be cured with this therapeutic approach.
Repetitive EA evokes a long-lasting response, suggesting that this therapy may be suitable for treating clinical hypertension.
Taken together these results suggest that microglial movement may be part of the long-lasting response of brain tissue to SD and could thus be a target for future work examining the role of microglia in SD susceptibility and by extension migraine.
The current case is the first to report objective, long-lasting response to pazopanib.
A long-lasting response was defined as no cutaneous or in-transit relapse after a minimum of six months.
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