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These observations suggested that co-delivery of HCMV polyepitope and gB vaccine can induce long lasting memory T cells immunity and antibody responses.
In agreement, reduction in the LCMV antigenic load after ribavirin treatment enhanced the contribution of early transferred cells to the long lasting memory pool.
Successful vaccination relies on the ability of vaccines to activate the adaptive immune system and induce long lasting memory responses.
Naïve CD4+ cells can be activated by the encounter with antigen via peptide/MHC class II TCR and differentiate into T effectors and long lasting memory T cells.
This paradigm, with its long lasting memory of the CS-US association provides easier implementation of tests focusing on memory acquisition, forgetting and extinction, and it is less physically demanding than the water maze test.
Since AH1, as most tumor antigens, is weakly immunogenic, deletion of dominant regions harboring both murine and human CTL epitopes in Fr-C (i.e., domain 2) directs the immune system towards the tumor antigen, thereby inducing strong CD8+ anti-tumor immunity and long lasting memory in mice.
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Damage limited to the hippocampal region produces long-lasting memory impairment in monkeys.
The brain's resident immune cells retain a long-lasting memory of peripheral inflammation.
The Northwestern study isn't the only attempt at unraveling long-lasting memory.
Our results suggest that strong PCC activity, in combination with strong LIFG activity, supports long-lasting memory.
It is possible, that the autoimmune response in NT1 is not strong enough to establish a long-lasting memory response in all patients.
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