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While both long insoluble and short soluble forms of OPA1 are found at the cristae junctions, it is the short form that is reported to be anti-apoptotic.
This seemingly small change results in the polymerisation of deoxygenated HbS monomers into long insoluble multi-stranded fibres of approximately 21.5 nm diameter.[ 2, 3] Thus, HbS polymerisation leads to deformation of the red blood cells and occlusion of capillaries, thereby causing haemolytic anaemia, susceptibility to serious infections, stroke, as well as chronic damage to vital organs.
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"What I've been trying to document over the past year is one of Africa's longest and most insoluble conflicts beginning to enter its endgame," Anderson says.
Cutinase is known for its hydrolytic activity for a variety of esters ranging from soluble p-nitrophenyl esters to insoluble long-chain triglycerides.
This group of enzymes is well known for its activity towards substrates with a range of different sizes of carbon chains and although non-specific esterases are more active on short acyl chain esters, lipases have the capability to catalyze the hydrolysis of carboxylic ester bonds of water-insoluble long chains including natural fat [ 4].
A line like "I'd sooner drown in bed forever with the women from my twenties, painting a sky of orgasms, acting insoluble" abuts long quotations from Trotsky.
Thrombin, in turn, catalyzes the conversion of fibrinogen (factor I a soluble plasma protein into long, sticky threads of insoluble fibrin (factor Ia).
The difficulty in achieving audibility to an audience of thousands, disposed around three-fifths to two-thirds of a full circular orchestra in the open air, seems to have been insoluble so long as the performer remained in the orchestra.
"They survived in order to create an answer to what appeared for too long to be an insoluble problem: how to make the Jewish state legitimate in the eyes of those who regard themselves as its victims.
It shows the Middle East crisis as insoluble as long as enemy refuses to listen to enemy.
According to Pavlov, the union's problems remained insoluble as long as Gorbachev retained so much power and had limited time to address important issues.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com