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Finally, it must retain a relatively large cloning capacity for carrying large therapeutic genes as well as long expression control DNA elements.
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Such long distance expression control has been described for several transcription factors in locus control regions, epitomized by the β-globin locus (for review, see [46]).
The dynamic epitranscriptome: N6-methyladenosine and gene expression control.
Coordinated gene expression controlled by long-distance enhancers is orchestrated by DNA regulatory sequences involving transcription factors and layers of control mechanisms.
Coordinated gene expression controlled by long-distance enhancers is recognised to fall into a number of different, but possibly overlapping, mechanistic classes.
Another important element of gene-expression control is epigenetic modification.
In contrast, the long-term control of gene expression induced by growth factors and the changes in gene expression, which occur during development, is generally (with few exceptions) irreversible.
This indicated that Shh acted directly at long range to control gene expression and cell fate in the neural tube.
Although the ability of Shh to induce distinct neuronal subtypes in a concentration-dependent manner suggested that Shh acted directly at long range to control gene expression, no direct in vivo observation of a gradient of Shh protein had been made.
Kleinjan, D.A. & van Heyningen, V. Long-range control of gene expression: emerging mechanisms and disruption in disease.
Our results therefore provide a global view of chromatin dynamics and a resource for studying long-range control of gene expression in distinct human cell lineages.
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