There is interest in surrogate end points for clinical trials of chronic kidney disease progression because currently established end points—end-stage renal disease (ESRD) and doubling of serum creatinine level are late events, requiring large clinical trials with long follow-up.
The cliques in blogging have been long established, and at the end of the day many will find personal interest in reading a list of the top 100 blogs in their own favorite vertical.
Mr. Herzfeld and others say investors have not placed much value on these and other holdings because the fund is a closed-end investment, a structure that, while long established, is poorly understood.
The best British galleries are here, too, from the long established to the Hoxton groovies, from artist-run Glasgow galleries to East End cult spaces.
Finally this year, the long established re-circulation of petrodollars back into the U.S. financial system came to an end -- according to BNP. "The oil producers will effectively import capital amounting to $7.6 billion.
"This has been long established".
But this is a long established tendency.
He had long established ties with Al Qaeda".
This principle is well understood and long established.
"Those rules are intentional, long established and carefully considered.
Both tools are long established.
