Limitations of MRI include the cost, availability, and long duration of scanning, as well as a relative paucity of skilled readers and technologists.
However, high costs, limited availability, and long duration of the MRI examination limit wide application of MRI for AAI.
The large numbers, long duration of follow-up and availability of detailed individual-level data which was systematically entered into an electronic database are major strengths.
Furthermore, the high cost of running a chamber study (continuous medical and technical cover) and limited availability of long duration hypoxia facilities capable of accommodating large cohorts contributed to this decision.
Response rates are clearly improved with three-drug regimens, although demonstration of a significant survival advantage is difficult given the large numbers of patients and the long duration of follow-up required, and the availability of effective salvage therapies.
This underlines the methodological limitations of statistical distributions which primarily rely on the fact that the flow in a river is not altered through unnatural ways and the data availability is continuous and of long duration at every station along the river.
Despite well-known adverse effects (histamine release, hypotension, respiratory depression, tolerance and dependence, and accumulation of active metabolites) and long duration of action, morphine is likely to keep its place in the ICU because of familiarity, availability, and cost-effectiveness, at least in comforting dying patients, particularly in cost-restricted settings.
"It was for a long duration.
The complexity was compounded by the franchise's long duration.
That is, we need high-resolution and long duration measurements to fully understand trends.
