Life expectancy was 40 at best, the working week was long, disease was rife and diets were poor.
"He looked like someone who was at the end stage of a long disease process," he said.
There was no self-pity when he wrote about "this long disease, my life", because that was what it was.
He suffered from tuberculosis of the bone that left him hunched and deformed, leading him once to lament "this long disease, my life".
The present case demonstrated good outcomes with resection of metastatic disease and relatively long disease-free survival.
In other cases authorsdescribed the presence of cognitive deficit only after a long disease duration [7, 8].
These four metastases belong to two patients with a long disease and therapy history (2 and 4 years).
Moreover resection is most likely to be warranted in patients presenting after a long disease-free interval following primary cancer treatment, suggesting a biological pattern of slow growth.
The SLPQRW score was also reduced in patients with long disease duration, probably because headache and especially migraine persistence may aggravate this aspect of sleep.
Non-fatal fractures have been reported to occur in up to 6% of AS patients, especially in patients with long disease duration [16].
Conclusion: In a long-term follow-up, TMJ involvement proved frequent in the studied patients and was associated with long disease duration and previous pain on jaw opening.
