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Subjects in the short and long boosting interval groups differ in which strain of BCG they were vaccinated with.
There were no significant differences in plateau responses 24 weeks after vaccination, when the short and long boosting intervals were compared.
ClinicalTrials.gov NCT00427453 (short boosting interval), NCT00427830 (long boosting interval), NCT00480714 (BCG alone) In 2003, there were 8.8 million new cases of tuberculosis (TB) throughout the world and 1.7 million deaths [1].
The data presented here investigating the immunogenicity of a short boosting interval between BCG vaccination and MVA85A boosting were then compared with the data from the long boosting interval clinical trial previously published [14].
The short boosting interval subjects presented here were all vaccinated with the SSI strain of BCG, whereas the long boosting interval group previously published were vaccinated with Glaxo BCG.
A limitation of the work presented here is that the short boosting interval BCG prime MVA85A boost trial and the long boosting interval trial previously published were not performed as a single study.
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