The organizational model could then, within the design of the system, be mapped to the software behavior through the use of logical agents.
The universal presence of oncogenic KRAS mutations leading to phosphorylation of Erk, as well as the fact that MEK-ERK signaling can activate transcription of MUC2, suggests that MEK inhibitors would be logical agents to explore in this disease.
In fact, several bio techno)logical agents have been investigated both for the management of the articular gout symptoms, targeting mainly interleukin-1 β, as well as urate-lowering therapies such as recombinant uricases.
The availability of new effective drugs that are able to modulate the inflammatory cascade of RA is another factor that contributes to this "change of perspective" in RA treatment; these drugs are generally known as bio techno)logical agents and may target TNF [ 15], CD20+ cells [ 16], IL-6 [ 17], and T-cells costimulation [ 18].
When establishing a logical form agents choose inter alia a formal language, a semantics (e.g., extensional vs. intensional), a notion of validity, etc.
By ordering agents in a hierarchical structure (multiple simple agents can exists on the same platform e.g., inside a VM), preprocessing of detected simple events and information sharing between logical associated agents leads to a reduction of network load [41].
Here, P1 and P2 are probability functions, which can have various interpretations, such as the probabilities of two agents, logical and statistical probability, or the probabilities of one agent at different moments in time (Miller 1966; Lewis 1980; van Fraassen 1984; Halpern 1991).
Malignancies with high concentrations of activated NF- κB, such as breast cancer, are logical targets for agents that interrupt this pathway (Orlowski and Dees, 2003).
Much work is being done to render logical means combining the agent logics discussed and the logical techniques from mainstream computer science for the verification of distributed systems (from section 3), but we are not there yet…!
Focus is also given on the customizable logical rule-bases for agent reasoning required in decision support.
