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Optimal sample sizes are derived for the case where the linearizing transformation is log(dose).
A range of link functions relating expected response to log(dose) are considered.
Regression analysis revealed a significant correlation between log dose and insect mortality (P < 0.05).
In Schild regression, a plot is made of the log (dose ratio-1) versus the log concentration of antagonist for a range of antagonist concentrations.
Previous chronoamperometric studies have shown a dose-dependant relationship between the peak of extracellular DA and log dose of applied DA through a micropipette in rat striatum [18].
The IC50 values were calculated from log dose response curves.
Similar(26)
The LD50 and ED50 values were calculated using the log dose-probit analysis [ 23].
Estimates of IC 25 and IC 50 values were based on the interpolation of data from log dose-response curves.
IC50 values were calculated from log dose-response curves using Prism 6 software (GraphPad Software Inc., La Jolla, CA, USA).
The median lethal dose (LD50) was estimated by the log dose-probit analysis method [ 17, 18] based on mortality recorded within 24 h.
The AMP dose required to reduce FEV1 by 20% (PD20AMP) was estimated by an interpolation between the two last doses on the log dose-response plot [ 8].
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