However, the most intriguing case so far is the MHC loci, wherein humans consistently fail to find significant associations with gut microbial compositions, either in candidate gene approaches or even in the recent GWAS (see later).
In this article, we show that the firm can be viewed as a locus of socialization wherein employees with heterogeneous work attitudes can be motivated and coordinated through adherence to a social norm of effort.
Proof of this concept was provided using mouse models wherein the locus that codes for Cdk4, one of the important gate-keepers of the mammalian cell cycle machinery, was targeted by genetic recombineering [36], [53].
We compared the expression of genes in winter-habit (winter Norstar and winter Manitou) and spring-habit (spring Manitou and spring Norstar)) cultivars, wherein the locus for the vernalization gene Vrn-A1 was swapped between the parental winter Norstar and spring Manitou in the derived near-isogenic lines winter Manitou and spring Norstar.
Next, we examined the effects of mre11 SUPsae2 ∆ alleles on Sae2-dependent DSB repair by single-strand annealing (SSA), using a system wherein a chromosomal locus contains an HO endonuclease cleavage site flanked by two direct sequence repeats.
To more specifically evaluate the FUDR resistant phenotypes we determined the IC50 value of the EMS mutants and compared them with the parent RH strain and parasites wherein the UPRT locus was genetically deleted (ΔUPRT).
Together with information from previous investigations, our study suggests that locus heterogeneity exist for FECD, wherein mutations of several genes on different chromosomes may produce a common disease phenotype.
Allele size variations favored multiplexing of fluorescent based automated DNA genotyping applications, wherein upto 18 loci were analyzed in a single run with 5 dye format (Faria et al. [2010]).
Figure 1 illustrates the roles of these loci within the female germline, wherein the functions and interactions of these genes are more thoroughly understood.
Our results are in agreement with earlier findings [ 19] wherein segregation distorted loci were distributed over eight chromosomes viz., 2, 3, 4, 6, 7, 8, 9 and 10.
