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The locus origin of the J H sequences in the rearrangements could not be unambiguously established.
Due to the ambiguous information from other species, we did not assign locus origin to any of the alleles.
However this sequence characteristic alone is not enough to refer locus origin, as it is not deterministic for one of the loci.
The Neighbour-joining tree does not solve the question of locus origin either, as none of the Lesa allele groups gets significant bootstrap support.
Most studies use the NCBI BLAST search for identification of locus origin and this might be sometimes misleading, as locus identification is commonly referred from distantly related taxa if no species specific sequence data is available.
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Only those axons arising from thalamic nuclei appropriate for the cortical locus of origin of the grafted cells respond to the guidance signals.
Here, then, is an early locus of origin for NOW.
Analyses of all tags revealed that HERV-W env-like sequences appeared to be derived from chromosome 7q21.2 but because of the short length of the present tags, a refined assignment of chromosomal locus of origin could not be performed.
One Type I gene variant is found on the Type II cluster suggesting a common genomic locus of origin for the α-keratins in amniotes [ 7].
Duplication events in the genomic regions containing variable genes only occurred in the TRG1 locus, giving origin to three (TRGV8-1, TRGV9-1, TRGV9-1) and 6 (TRGV11-1, TRGV3-2, TRGV10-1 TRgenesTRGV10-1, TRGV4,) genes in the TRGC3 and TRGC5 cassettes respectively (Fig. 2).
In another study centered on colorectal cancer, his team was able to show that intronic RNAs bind to EZH2, the catalytic component of PRC2, and guide it to repress the locus of origin.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com