Exact(10)
The bootstrap confidence intervals for gene effect did not include zero for protein percent on chromosome 2 and fat yield, protein yield, and SCS on chromosome 7. Quantitative trait locus heterozygosity was 33%, which is consistent with the hypothesis that only two alleles are segregating with unequal allele frequency.
First, we tested for heterozygote advantage by fitting a binomial General Linear Model (GLM) with disease status (0, 1) as the response and single locus heterozygosity (scored as 0 or 1) plus 'group' and the heterozygosity-group interaction terms as predictor variables.
Per locus heterozygosity excess and deficiency probability values for each population and across all populations.
The clonal stock culture was initiated from a single Paramecium cell to minimize locus heterozygosity.
The data should be formatted in a plain text file with six required columns (see the example data in GigaDB [ 6]): locus name, chromosome, location, locus heterozygosity in population 1, locus heterozygosity in population 2, locus FST.
For animals genotyped with the 770 K assay (510 Angus, 491 Hereford), sex was assigned as male if non-paX locus heterozygosity was <0.03 and Y locus call rate was ≥0.5, female if non-paX locus heterozygosity was ≥0.03 and Y locus call rate was <0.5, and Klinefelter if non-paX locus heterozygosity was ≥0.03 and Y locus call rate was ≥0.5.
Similar(50)
First of all, we demonstrate how the choice of method used to calculate multi-locus heterozygosity can influence ones results.
A second challenge when investigating the individual or population level consequences of heterozygosity is how to transform heterozygosity to generate a statistically comparable estimator of multi-locus heterozygosity.
Nonetheless, multi-locus heterozygosity has been widely reported to influence fitness (e.g. [37]), even if the genetic processes it captures are not well understood.
The simplest heterozygosity measure is individual multi-locus heterozygosity (MLH), defined as the proportion of heterozygous loci within an individual [19].
Individual multi-locus heterozygosity (MLH), standardised heterozygosity (Hs) and homozygosity weighted by loci (HL) all showed a substantial decrease in variance as the number of markers at which an individual was genotyped increased (Figure 1).
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