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A screen often has to present information clearly and also act as the locus for interacting with the system.
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(2) The correlation between locus distances in human and mouse genomes was significantly higher for interacting loci than for randomly selected pairs of loci of the same span distribution, supporting the higher conservation of synteny for interacting pairs (PCC = 0.90, FDR = 0.004; Figures 4B and S4H).
PFAM domains for interacting pairs.
Another is necessary for interacting with thrombomodulin.
As its target genes are still unknown despite the original cloning of Asr1 cDNA 20 years ago, we examined the tomato genome for specific loci interacting in vivo with this conspicuous protein.
The above results support the idea that causative genetic loci for ALS interact genetically with each other.
Model 4 contains three ground-truth loci interacting together.
To cover a broad spectrum, we set three levels (0.10, 0.25, and 0.50) of minor allele frequency (MAF) for interacting loci.
However current chip and Hapmap coverage is quite good and this is problematic for all statistical methods used to test for allelic association The results of these simulations provide clues as to how to perhaps more effectively search for interacting loci.
Our comparative examination of these methods suggests that continued research into methods that test for interacting loci is necessary to expand the tools available to researchers and to achieve improved power for detecting complex interactions, along with accurate assessment of statistical significance.
Future studies should investigate a complete adaptive walk, allowing for mutations at multiple loci to interact via dominance, epistasis, and linkage.
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