Most of the subscales showed good internal consistency, with the only exception being the Locus factor.
We note that while some factors (e.g. Hsp90) buffer genetic variation at many loci, factors that buffer only one or a few polymorphisms fit equally well into the definition of GR.
With MDR, we pooled multi-locus factors into high-risk and low-risk groups, thereby reducing the otherwise high-dimensional data to a single variable and permitting an investigation of individual GST genes, gene combination effects, and GST-tobacco smoking interactions.
For the successfully amplified loci, factors affecting incidence of polymorphism were evaluated using generalized linear models treating SSR type, SSR location (cf. exonic, intronic and intergenic regions) and SSR repeat motif (cf. di- and trinucleotide repeats) as factors.
Key elaborations of the construct focused on the "locus" of factors presumed to enhance child resilience.
Note.-Tests for comparisons between TW and AR were bifactorial mixed ANOVAs with group (AR and TW) and locus as factors.
In addition to the dynamic nature of the CRISPR locus, other factors might have influenced the phenomenon where only phages infecting some groups of bacteria show a depletion in PAMs, while other phages do not.
When duplicate history bias is removed by calculating GO term frequencies of the pre-genome-duplication set of loci, transcription factors are still overrepresented (11/31 loci, or 35%).
Alternatively, if allelic dropout is caused by locus-specific factors such as differences across loci in the binding properties of the primers or polymerase, we instead expect a positive correlation across loci between missing data and locus homozygosity.
Here we perform a genome-wide gain of function screen of B. pseudomallei strain K96243 to identify loci encoding factors with anti-macrophage activity.
Libraries of recombinant E. coli each carrying end-sequenced B. pseudomallei genomic fragments (fosmids or Bacterial Artificial Chromosomes (BACs)) were used to identify loci encoding factors cytotoxic to the murine macrophage cell-line J774-2.
