Sentence examples for locus developed from inspiring English sources

We thus studied the human SupT1 T-cell line with intensified RNAi developed by Llano et al. [37], and mouse cells containing homozygous gene trap mutations at the LEDGF/p75 locus developed by Sutherland and coworkers [42].

For instance, mice lacking the miR-1-2 genomic locus developed a range of abnormalities such as ventricular septal defects, cardiac arrhythmia, and myocyte hyperplasia with nuclear division of cardiomyocytes persisting postnatally [ 37].

Both SHIP−/− and SHIPΔIP/ΔIP that harbour deletions in exons encoding different regions in the SHIP1 locus developed ileitis with comparable frequency with 25 of 26 (96%) of SHIP−/− mice, and 24 of 26 (92%) of SHIPΔIP/ΔIP mice affected with comparable mean ileitis inflammatory grades of 4.2±2.1 and 4.0±2.2, respectively.

The objectives of this study were to identify genes at Glu-A3 locus, develop the STS markers, and establish multiplex PCR with the STS markers for Glu-A3 alleles.

While associations between mutations at different loci remain small even under inbreeding, each viability locus develops an association with the modifier of the rate of self-fertilization that substantially affects the evolution of the breeding system.

Diploid individuals that are heterozygous at the sex locus develop into females, whereas hemizygous (haploid) and homozygous diploid individuals develop into males [6], [8].

Tumours with two allelic mutations at a mismatch repair locus develop replication errors (RERs).

Under this system, individuals heterozygous at the polyallelic sex-determining locus develop into diploid females and hemizygotes develop into haploid males.

Bees that are heterozygous at the csd locus develop into females, whereas bees that are homozygous or hemizygous at csd develop into males.

As mentioned earlier, congenic mice with the NZW-derived Sle1 locus develop spontaneous T-cell activation and autoantibody formation (Mohan et al., 1998).

However, mice with homozygous deletion of the Neu1 locus develop clinical abnormalities reminiscent of early-onset sialidosis in children, including severe nephropathy, progressive edema, splenomegaly, kyphosis and urinary excretion of sialylated oligosaccharides (de Geest et al., 2002).