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After plotting the differences in rolling average allele frequencies between beef and dairy cattle against the third locus coordinate within a five-locus sliding window, we observed large fluctuations about the axis on both chromosomes (Figs 2 & 3).
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Plasmid pML514 was constructed by inserting in the pGEM7Zf EcoRI site a 900-bp fragment containing part of the MATα locus (coordinates 200870 to 201587 on chromosome III).
For example, HOTTIP (a lincRNA transcribed from the 5' end of the HOXA locus) coordinates the activation of several HOXA genes; chromatin looping brings HOTTIP close to its targets, and this drives H3K4 trimethylation and transcription [ 35].
A read was denoted 'aligned' to a locus if its sequence alignment to the genomic reference sequence (NCBI build 36.2) fell within the boundaries of the locus coordinates on the chromosome.
Details of our findings at all previously reported schizophrenia CNV risk loci, with locus coordinates, are provided in Supplementary Material, Table S3a.
Here, we defined locus coordinates as the greater of the transcript start-to-stop span or 60 kb centered on the loci.
In addition, tiled 30 mer probes were generated across the Pina and Pinb genes (locus coordinates: bases 23881 26520 (Pina) and 41041 45000 (Pinb)).
The database allows easy systematic retrieval of comprehensive information about simple and compound microsatellites, microsatellite clusters and their locus coordinates in 31 sequenced eukaryotic genomes.
It has been found that the larger the phasing sample size, the greater the haplotype phasing accuracy [ 15].Figure 2 compares observed probabilities of crossover events on Angus BTA15 using UMD3.1 versus USDA-AIPL locus coordinates.
The isomiRs may either form an miRNA locus to coordinate target mRNA regulation (19) or their target transcripts could also potentially differ (17).
They can serve as a locus for coordinating the involvement of various gatekeepers, such as lawyers and investment professionals.
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