Sentence examples for locus away from from inspiring English sources

However, activation of HXK1 by an alternative pathway based on the transactivator VP16 moved the locus away from the nuclear periphery and abrogated the normal induction of HXK1 by galactose.

Firstly, the filling-in phenomenon across pathological scotomas [ 14]; secondly, the use of a preferred retinal locus away from the scotoma boundary [ 15]; moreover, probably, the averaging of crowded stimuli [ 16].

These changes were also accompanied by downregulation of the transcriptional activity and relocation of the keratinocyte-specific gene loci away from the sites of active transcription toward the heterochromatin-enriched repressive nuclear compartments in p63-null cells.

Our results suggest that availability of genomic regions for activation by lineage-specific factors is regulated in part through dynamic chromatin-nuclear lamina interactions and that competence of a progenitor cell to respond to differentiation signals may depend upon coordinated movement of responding gene loci away from the nuclear periphery.

Previous studies suggested a role for chromatin modifications in large-scale movement of loci away from heterochromatic regions and the subsequent changes in transcription and replication timing in the human β-globin locus [47] and the CFTR locus [48].

Other lncRNAs act in trans by recruiting the histone-modifying enzymes to different loci away from the lncRNA transcription locus.

At about the time of L3-R3 focuseparationon, the locus/sister loci moved away from the outer edge of the nucleoid and toward midcell.

For instance, during cell differentiation, loci move away from the lamina as they become active (e.g., [ 104]); a classic example is the activation of the IgH locus [ 105].

Interestingly, NCTC10247 (reduced virulence strain) had a drastic rearrangement that left the rrn locus 1.1 Mb away from the origin of replication and also resulted in a chromosome with differently sized replichores (fig. 4 B ).

Another gene, PDR8, encoding a pleiotropic drug resistance transcription factor lies in the same locus, 25 kbp away from HAP1, and may control some of these genes (Additional file 5).

Considering that the two STR loci are still far away from the ADH1B locus, we also estimate the age of the ADH1B*47His based on the phased SNP haplotypes from the HapMap dataset (see Additional file 3).