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The timing of hazardous drinking occurring during fetal development dictates the locus and extent of neural and facial dysmorphology sustained, resulting in fetal alcohol spectrum disorders (FASD).
This design allowed us to identify the locus and extent of a potential disconnection by comparing, within individual animals, the densities of labeled fibers and terminals in a normal hemisphere with those in a hemisphere with the lesion.
However, it is often difficult to assess the precise locus and extent of damage in such patients and to ascertain that only the hippocampus and no other medial temporal regions are affected.
We first documented the locus and extent of the brain lesion from the computerized tomography of Phineas Gage's skull and the magnetic resonance images of Louis Victor Leborgne's brain, Broca's first patient, and Henry Gustave Molaison.
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Additional file 1: Table S3 provides a summary of the loci and extent of the imputed regions.
The individuals with homozygous and compound heterozygous ZFP57 mutations have mosaic patterns of hypomethylation regarding both the number and combination of affected imprinted loci and the extent of hypomethylation in each locus (Supplementary Table 1).
All rainbow trout had previously been genotyped for seven microsatellite loci, and the extent of admixture with secondary releases from farmed escapees had been estimated for each study river (details in Consuegra et al. 2011).
They are mainly encoded as discrete interference modules, separate from CRISPR loci, and the extent to which they influence spacer uptake remains unclear given that very few Type III interference gene cassettes are coupled directly with spacer-acquisition gene cassettes (Table 2).
The presentation focuses on 1) regional patterns of cerebral and white matter atrophy, 2) evidence of septal abnormalities, including cavum septum pellucidum or fenestrations, 3) pallor of the substantia nigra and locus coeruleus, 4) extent and anatomic distribution of neuronal loss and gliosis, 5) immunohistochemistry (p-tau, β-amyloid, pTDP-43 and α-synuclein) and 6) vascular pathology.
Second, both visual inspection of the sequence alignment and tests of the four-gamete rule [ 32] indicate that the mtDNA locus (and to a lesser extent, RAG2) have been affected by homoplasy (or alternately, recombination).
In many DA cases, volume loss occurs before the hippocampus is fully developed, and yet little is known about the locus, extent, and distribution of damage in these cases.
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